Involvement of TRP channels in the CO 2 chemosensitivity of locus coeruleus neurons 3 4
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چکیده
4 Ningren Cui*, Xiaoli Zhang*, Jyothirmayee S. Tadepalli, Lei Yu, Hongyu Gai, James Petit, 5 Ravi T. Pamulapati, Xin Jin and Chun Jiang 6 7 Department of Biology, Georgia State University, 100 Piedmont Avenue, Suite 495 8 P.O. Box 4010, Atlanta, GA 30302 9 10 11 12 13 Running head: TRP channels in neuronal CO2 chemosensitivity 14 15 Number of text pages: 28 16 17 Number of display items: 10 18 19 Number of online materials: 3 20 21 Abstract word count: 250 22 23 Main text word count: 8266 24 25 26
منابع مشابه
Involvement of TRP channels in the CO₂ chemosensitivity of locus coeruleus neurons.
Catecholaminergic neurons in the locus coeruleus (LC) play a role in the ventilatory response to hypercapnia. Here, we show evidence for the involvement of transient receptor potential (TRP) channels. We found that the input resistance was reduced during an exposure to 8% CO(2) in ~35% LC neurons in mouse brain slices, accompanied by depolarization and higher firing activity. The neuronal respo...
متن کاملInvolvement of TRP channels in the CO2 chemosensitivity of locus coeruleus neurons
Cui N, Zhang X, Tadepalli JS, Yu L, Gai H, Petit J, Pamulapati RT, Jin X, Jiang C. Involvement of TRP channels in the CO2 chemosensitivity of locus coeruleus neurons. J Neurophysiol 105: 2791–2801, 2011. First published March 23, 2011; doi:10.1152/jn.00759.2010.—Catecholaminergic neurons in the locus coeruleus (LC) play a role in the ventilatory response to hypercapnia. Here, we show evidence f...
متن کاملPostnatal developmental alterations in the locus coeruleus neuronal fast excitatory postsynaptic currents mediated by ionotropic glutamate receptors of rat
Introduction: In the present work, spontaneous postsynaptic currents were assessed to investigate the postnatal development of excitatory postsynaptic currents in locus coeruleus neurons. Methods: In this study, AMPA and NMDA receptor-mediated spontaneous synaptic currents in the neurons of locus coeruleus were assessed using whole cell voltage-clamp recording during the first three weeks. ...
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As one of the most important diffused brain modulatory systems, the nucleus locus coeruleus (LC) receives most of its afferents from the nucleus paragigantocellularis (PGi) and plays a major role in the control of drug dependence and some emotional and exciting states. For detailed investigation of the effect of morphine on relationship between these two brain stem nuclei, the activity of the r...
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As one of the most important diffused brain modulatory systems, the nucleus locus coeruleus (LC) receives most of its afferents from the nucleus paragigantocellularis (PGi) and plays a major role in the control of drug dependence and some emotional and exciting states. For detailed investigation of the effect of morphine on relationship between these two brain stem nuclei, the activity of the r...
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